Publications

2024

van Belle GJ, Zieseniss A, Heidenreich D, Olmos M, Zhuikova A, Möbius W, Paul MW, Katschinski DM. Cargo-specific effects of hypoxia on clathrin-mediated trafficking. Pflugers Arch. 2024 Jan 31. doi: 10.1007/s00424-024-02911-6.

2023

Bassot A, Chen J, Takahashi-Yamashiro K, Yap MC, Gibhardt CS, Le GNT, Hario S, Nasu Y, Moore J, Gutiérrez T, Mina L, Mast H, Moses A, Bhat R, Ballanyi K, Lemieux H, Sitia R, Zito E, Bogeski I, Campbell RE, Simmen T (2023) The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria. Cell Rep 42(1):111899. doi: 10.1016/j.celrep.2022.111899.

Cao-Ehlker X, Fischer C, Lu K, Bruegmann T, Sasse P, Dendorfer A, Tomasi R (2023) Optimized Conditions for the Long-Term Maintenance of Precision-Cut Murine Myocardium in Biomimetic Tissue Culture (2023) Bioengineering (Basel) 10(2):171. doi: 10.3390/bioengineering10020171.

Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Böckmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann T, Belousov VV, Katschinski DM (2023) IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart. Nat Commun 14(1):2123. doi: 10.1038/s41467-023-37744-x.

Slowik EJ, Stankoska K, Bui NN, Pasieka B, Conrad D, Zapp J, Hoth M, Bogeski I, Kappl R (2023) The calcium channel modulator 2-APB hydrolyzes in physiological buffers and acts as an effective radical scavenger and inhibitor of the NADPH oxidase 2. Redox Biol 61:102654. doi: 10.1016/j.redox.2023.102654.

Chowdhury A, Boshnakovska A, Aich A, Methi A, Vergel Leon AM, Silbern I, Lüchtenborg C, Cyganek L, Prochazka J, Sedlacek R, Lindovsky J, Wachs D, Nichtova Z, Zudova D, Koubkova G, Fischer A, Urlaub H, Brügger B, Katschinski DM, Dudek J, Rehling P. Metabolic switch from fatty acid oxidation to glycolysis in knock-in mouse model of Barth syndrome.
EMBO Mol Med. 2023 Aug 3:e17399. doi: 10.15252/emmm.202317399.

Stejerean-Todoran I, Bogeski I. (2023) Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness. EMBO J. 28:e114986. doi: 10.15252/embj.2023114986.

Budde H, Mohr L, Bogeski I, Riggert J, Legler TJ. (2023) Extracorporeal photopheresis and the cellular mechanisms: Effects of 8-methoxypsoralen and UVA treatment on red blood cells, platelets and reactive oxygen species. Vox Sang. doi: 10.1111/vox.13489.

Cunha PP, Minogue E, Krause LCM, Hess RM, Bargiela D, Wadsworth BJ, Barbieri L, Brombach C, Foskolou IP, Bogeski I, Velica P, Johnson RS. (2023) Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy. Elife 11;12:e84280. doi: 10.7554/eLife.84280.

Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs: Shi R, Reichardt M, Fiegle DJ, Küpfer LK, Czajka T, Sun Z, Salditt T, Dendorfer A, Seidel T, Bruegmann T Cardiovascular Research 2023; 119(14): 2469–2481; doi: doi.org/10.1093/cvr/cvad141

2022

Asfaw KG, Liu Q, Eghbalian R, Purper S, Akaberi S, Dhakarey R, Münch SW, Wehl I, Bräse S, Eiche E, Hause B, Bogeski I, Schepers U, Riemann M, Nick P (2022) The jasmonate biosynthesis Gene OsOPR7 can mitigate salinity induced mitochondrial oxidative stress. PLANT SCI 316: 111156, doi: 10.1016/j.plantsci.2021.111156
 
Bapst AM, Knöpfel T, Nolan KA, Imeri F, Schuh CD, Hall AM, Guo J, Katschinski DM, Wenger RH (2022) Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin-producing cells. J CELL PHYSIOL 237(5): 2420, doi: 10.1002/jcp.30677
 
Bruegmann T, Smith GL, Lehnart SE (2022) Editorial: Cardiac optogenetics: Using light to observe and excite the heart. FRONT PHYSIOL 13: 1031062, doi: 10.3389/fphys.2022.1031062
 
Chauvistré H, Shannan B, Daignault-Mill SM, Ju RJ, Picard D, Egetemaier S, Váraljai R, Gibhardt CS, Sechi A, Kaschani F, Keminer O, Stehbens SJ, Liu Q, Yin X, Jeyakumar K, Vogel FCE, Krepler C, Rebecca VW, Kubat L, Lueong SS, Forster J, Horn S, Remke M, Ehrmann M, Paschen A, Becker JC, Helfrich I, Rauh D, Kaiser M, Gul S, Herlyn M, Bogeski I, Rodríguez-López JN, Haass NK, Schadendorf D, Roesch A (2022) Persister state-directed transitioning and vulnerability in melanoma. NAT COMMUN 13(1): 3055, doi: 10.1038/s41467-022-30641-9
 
Friedmann KS, Kaschek L, Knörck A, Cappello S, Lünsmann N, Küchler N, Hoxha C, Schäfer G, Iden S, Bogeski I, Kummerow C, Schwarz EC, Hoth M (2022) Interdependence of sequential cytotoxic T lymphocyte and natural killer cell cytotoxicity against melanoma cells. J PHYSIOL-LONDON 600(23): 5027, doi: 10.1113/JP283667
 
Gibhardt CS, Riemer J, Bogeski I (2022) Calcium and redox signals at mitochondrial interfaces: A nanoview perspective. CELL CALCIUM 103: 102550, doi: 10.1016/j.ceca.2022.102550
 
Gulaboski R, Bogeski I (2022) Review-Women's Contribution in the Pulse Voltammetric Theories and Applications: Pulse Voltammetry Stands on the Shoulders of Outstanding Women Electrochemists. J ELECTROCHEM SOC 169: -
 
Hoehne MN, Jacobs LJHC, Lapacz KJ, Calabrese G, Murschall LM, Marker T, Kaul H, Trifunovic A, Morgan B, Fricker M, Belousov VV, Riemer J (2022) Spatial and temporal control of mitochondrial H2 O2 release in intact human cells. EMBO J 41(7): e109169, doi: 10.15252/embj.2021109169
 
Jatho A, Zieseniss A, Brechtel-Curth K, Guo J, Böker KO, Salinas G, Wenger RH, Katschinski DM (2022) The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1+ Cells. CELLS-BASEL 11(4): -, doi: 10.3390/cells11040753
 
Katoshevski T, Bar L, Tikochinsky E, Harel S, Ben-Kasus Nissim T, Bogeski I, Hershfinkel M, Attali B, Sekler I (2022) CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca2+ via Mitochondrial NCLX. CELLS-BASEL 11(24): 1-19, doi: 10.3390/cells11243990
 
Kimoloi S, Sen A, Guenther S, Braun T, Brügmann T, Sasse P, Wiesner RJ, Pla-Martín D, Baris OR (2022) Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia. J CACHEXIA SARCOPENI 13(4): 2132, doi: 10.1002/jcsm.13026
 
Latif MU, Schmidt GE, Mercan S, Rahman R, Gibhardt CS, Stejerean-Todoran I, Reutlinger K, Hessmann E, Singh SK, Moeed A, Rehman A, Butt UJ, Bohnenberger H, Stroebel P, Bremer SC, Neesse A, Bogeski I, Ellenrieder V (2022) NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression. GUT 71(12): 2561, doi: 10.1136/gutjnl-2021-325013

Poschmann G, Bahr J, Schrader J, Stejerean-Todoran I, Bogeski I, Stühler K (2022) Secretomics-A Key to a Comprehensive Picture of Unconventional Protein Secretion. FRONT CELL DEV BIOL 10: 878027, doi: 10.3389/fcell.2022.878027

Shumanska M, Bogeski I (2022) Redoxing PTPN22 activity. ELIFE 11: 1-3, doi: 10.7554/eLife.79125

Stejerean-Todoran I, Gimotty PA, Watters A, Brafford P, Krepler C, Godok T, Li H, Bonilla Del Rio Z, Zieseniss A, Katschinski DM, Sertel SM, Rizzoli SO, Garman B, Nathanson KL, Xu X, Chen Q, Oswald JH, Lotem M, Mills GB, Davies MA, Schön MP, Bogeski I, Herlyn M, Vultur A (2022) A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells. NEURO-ONCOLOGY online: online, doi: 10.1093/neuonc/noac212

Stejerean-Todoran I, Zimmermann K, Gibhardt CS, Vultur A, Ickes C, Shannan B, Bonilla Del Rio Z, Wölling A, Cappello S, Sung HM, Shumanska M, Zhang X, Nanadikar M, Latif MU, Wittek A, Lange F, Waters A, Brafford P, Wilting J, Urlaub H, Katschinski DM, Rehling P, Lenz C, Jakobs S, Ellenrieder V, Roesch A, Schön MP, Herlyn M, Stanisz H, Bogeski I (2022) MCU controls melanoma progression through a redox-controlled phenotype switch. EMBO REP 23(11): e54746, doi: 10.15252/embr.202254746
 
Wagdi A, Malan D, Sathyanarayanan U, Beauchamp JS, Vogt M, Zipf D, Beiert T, Mansuroglu B, Dusend V, Meininghaus M, Schneider L, Kalthof B, Wiegert JS, König GM, Kostenis E, Patejdl R, Sasse P, Bruegmann T (2022) Selective optogenetic control of Gq signaling using human Neuropsin. NAT COMMUN 13(1): 1765, doi: 10.1038/s41467-022-29265-w

2021

Butt UJ, Steixner-Kumar AA, Depp C, Sun T, Hassouna I, Wüstefeld L, Arinrad S, Zillmann MR, Schopf N, Fernandez Garcia-Agudo L, Mohrmann L, Bode U, Ronnenberg A, Hindermann M, Goebbels S, Bonn S, Katschinski DM, Miskowiak KW, Nave KA, Ehrenreich H. Hippocampal neurons respond to brain activity with functional hypoxia. Mol Psychiatry. 2021 Feb 9. doi: 10.1038/s41380-020-00988-w.

Cappello S, Sung HM, Ickes C, Gibhardt CS, Vultur A, Bhat H, Hu Z, Brafford P, Denger A, Stejerean-Todoran I, Köhn RM, Lorenz V, Künzel N, Salinas G, Stanisz H, Legler TJ, Rehling P, Schön MP, Lang KS, Helms V, Herlyn M, Hoth M, Kummerow C, Bogeski I (2021) Protein signatures of NK cell-mediated melanoma killing predict response to immunotherapies. Cancer Res. 13:canres.CAN-21-0164-A.2021. doi: 10.1158/0008-5472.CAN-21-0164

Cheng YC, Chang YA, Chen YJ, Sung HM, Bogeski I, Su HL, Hsu YL, Wang HD (2021) The Roles of Extracellular Vesicles in Malignant Melanoma. Cells 10(10):2740. doi: 10.3390/cells10102740

de Cubas L, Pak VV, Belousov VV, Ayté J, Hidalgo E (2021) The Mitochondria-to-Cytosol H2 O2 Gradient Is Caused by Peroxiredoxin-Dependent Cytosolic Scavenging. ANTIOXIDANTS-BASEL 10(5): 731, doi: 10.3390/antiox10050731

Erdogan YC, Altun HY, Secilmis M, Ata BN, Sevimli G, Cokluk Z, Zaki AG, Sezen S, Akgul Caglar T, Sevgen İ, Steinhorn B, Ai H, Öztürk G, Belousov VV, Michel T, Eroglu E (2021) Complexities of the chemogenetic toolkit: Differential mDAAO activation by d-amino substrates and subcellular targeting. FREE RADICAL BIO MED 177: 132-142, doi: 10.1016/j.freeradbiomed.2021.10.023

Islam MR, Lbik D, Sakib MS, Maximilian Hofmann R, Berulava T, Jiménez Mausbach M, Cha J, Goldberg M, Vakhtang E, Schiffmann C, Zieseniss A, Katschinski DM, Sananbenesi F, Toischer K, Fischer A. Epigenetic gene expression links heart failure to memory impairment. EMBO Mol Med. 2021 Jan 20:e11900. doi: 10.15252/emmm.201911900.

Jatho A, Zieseniss A, Brechtel-Curth K, Yamamoto A, Coleman ML, Vergel Leon AM, Biggs D, Davies B, Pugh CW, Ratcliffe PJ, Katschinski DM. Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia. Circ Res. 2021 Feb 25. doi: 10.1161/CIRCRESAHA.120.318216.

Kelmanson IV, Shokhina AG, Kotova DA, Pochechuev MS, Ivanova AD, Kostyuk AI, Panova AS, Borodinova AA, Solotenkov MA, Stepanov EA, Raevskii RI, Moshchenko AA, Pak VV, Ermakova YG, van Belle GJC, Tarabykin V, Balaban PM, Fedotov IV, Fedotov AB, Conrad M, Bogeski I, Katschinski DM, Doeppner TR, Bähr M, Zheltikov AM, Belousov VV, Bilan DS (2021) In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model. REDOX BIOL 48: 102178, doi: 10.1016/j.redox.2021.102178

Kreitmeier KG, Tarnwoski D, Nanadikar MS, Baier MJ, Wagner S, Katschinski DM, Maier LS, Sag CM. CaMKIIδ Met281/282 oxidation is not required for recovery of calcium transients during acidosis. Am J Physiol Heart Circ Physiol. 2021 Jan 15. doi: 10.1152/ajpheart.00040.2020.

Kutschat AP, Hamdan FH, Wang X, Wixom AQ, Najafova Z, Gibhardt CS, Kopp W, Gaedcke J, Ströbel P, Ellenrieder V, Bogeski I, Hessmann E, Johnsen SA (2021) STIM1 Mediates Calcium-Dependent Epigenetic Reprogramming in Pancreatic Cancer. Cancer Res. 81(11):2943-2955. doi: 10.1158/0008-5472.CAN-20-2874

Muellenbroich MC, A Kelly, C Acker, G Bub, T Bruegmann, A Di Bona, E Entcheva, C Ferrantini, P Kohl, SE Lehnart, M Mongillo, C Parmeggiani, C Richter, P Sasse, T Zaglia, L Sacconi, GL Smith. Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review. Front 2021, 12, 769586. doi: 10.3389/fphys.2021.769586

Sargsyan Y, Bickmeyer U, Gibhardt CS, Streckfuss-Bömeke K, Bogeski I, Thoms S (2021) Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells. Life Sci Alliance 4(9):e202000987. doi: 10.26508/lsa.202000987

Smolyarova DD, Podgorny OV, Bilan DS, Belousov VV (2021) A guide to genetically encoded tools for the study of H2 O2. FEBS J -: -, doi: 10.1111/febs.16088

Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R. Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Theranostics 2021; 11(11):5569-5584. doi:10.7150/thno.53883.

Wegener JW, A Wagdi, E Wagner, DM Katschinski, G Hasenfuss, T Bruegmann, SE Lehnart. The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool. Front Physiol  2021, 12, 777770. doi: 10.3389/fphys.2021.777770

Wu H, Brand B, Eckstein M, Hochrein SM, Shumanska M, Dudek J, Nickel A, Maack C, Bogeski I, Vaeth M (2021) Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo. FRONT PHARMACOL 12: 734078, doi: 10.3389/fphar.2021.734078

Cokic M, T Bruegmann, P Sasse, D Malan. Optogenetic Stimulation of Gi Signaling Enables Instantaneous Modulation of Cardiomyocyte Pacemaking. Front Physiol  2021, 12, 768495. doi: 10.3389/fphys.2021.768495

2020

Gibhardt CS, Cappello S, Bhardwaj R, Schober R, Kirsch SA, Bonilla Del Rio Z, Gahbauer S, Bochicchio A, Sumanska M, Ickes C, Stejerean-Todoran I, Mitkovski M, Alansary D, Zhang X, Revazian A, Fahrner M, Lunz V, Frischauf I, Luo T, Ezerina D, Messens J, Belousov VV, Hoth M, Böckmann RA, Hediger MA, Schindl R, Bogeski I. Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry. Cell Reports 20;33(3):108292 (2020).

Asfaw KG, Liu Q, Xu X, Manz C, Purper S, Eghbalian R, Münch SW, Wehl I, Bräse S, Eiche E, Hause B, Bogeski I, Schepers U, Riemann M, Nick P. A mitochondria-targeted coenzyme Q peptoid induces superoxide dismutase and alleviates salinity stress in plant cells. Scientific Reports 14;10(1):11563 (2020).

Gibhardt, C.S., Ezeriņa, D., Sung, H.-M., Messens, J. & Bogeski, I. Redox regulation of the mitochondrial calcium transport machinery. Current Opinion in Physiology 17, 138-148 (2020).

Wang-Eckhardt L, Bastian A, Bruegmann T, Sasse P, Eckhardt M. Carnosine synthase deficiency is compatible with normal skeletal muscle and olfactory function but causes reduced olfactory sensitivity in aging mice. J Biol Chem. 2020 Oct 9:jbc.RA120.014188. doi: 10.1074/jbc.RA120.014188. Epub ahead of print. PMID: 33040025.

Selective optogenetic stimulation of fibroblasts enables quantification of hetero-cellular coupling to cardiomyocytes in a three-dimensional model of heart tissue.Funken M, Bruegmann T, Sasse P. Europace. 2020 Oct 1;22(10):1590-1599. doi: 10.1093/europace/euaa128.

Elif Levent, Claudia Noack, Laura C. Zelarayán, Dörthe M. Katschinski, Wolfram-Hubertus Zimmermann, Malte Tiburcy. Inhibition of Prolyl-Hydroxylase Domain Enzymes Protects From Reoxygenation Injury in Engineered Human Myocardium. Circulation. 2020, 142 (17) 1694–1696.

Manuel Valiente, Amanda E D Van Swearingen, Carey K Anders, Amos Bairoch, Adrienne Boire, Paula D Bos, Diana M Cittelly, Neta Erez, Gino B Ferraro, Dai Fukumura, Brunilde Gril, Meenhard Herlyn, Sheri L Holmen, Rakesh K Jain, Johanna A Joyce, Mihaela Lorger, Joan Massague, Josh Neman, Nicola R Sibson, Patricia S Steeg, Frits Thorsen, Leonie S Young, Damir Varešlija, Adina Vultur, Frances Weis-Garcia, Frank Winkler. (2020) Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines. Cancer Res. 2020 Jul 8. doi: 10.1158/0008-5472.CAN-20-0291

Matteo Beretta, Celio XC Santos, Chris Molenaar, Anne D Hafstad, Chris CJ Miller, Aram Revazian, Kai Betteridge, Katrin Schröder, Katrin Streckfuß‐Bömeke, James H Doroshow, Roland A Fleck, Tsung‐Ping Su, Vsevolod V Belousov, Maddy Parsons, Ajay M Shah. (2020) Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival. The Embo Journal 2020 Aug 10; EMBO J (2020) 39: e103530 doi: 10.15252/embj.2019103530

Lu S, Liao Z, Lu X, Katschinski DM, Mercola M, Chen J, Heller Brown J, Molkentin JD, Bossuyt J, Bers DM. (2020) Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes. Circ Res. 2020 Mar 5.

Pak VV, Ezeriņa D, Lyublinskaya OG, Pedre B, Tyurin-Kuzmin PA, Mishina NM, Thauvin M, Young D, Wahni K, Martínez Gache SA, Demidovich AD, Ermakova YG, Maslova YD, Shokhina AG, Eroglu E, Bilan DS, Bogeski I, Michel T, Vriz S, Messens J, Belousov VV. (2020) Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function. Cell Metab. 2020 Mar 3;31(3):642-653.e6.

Pacheu-Grau D, Wasilewski M, Oeljeklaus S, Gibhardt CS, Aich A, Chudenkova M, Dennerlein S, Deckers M, Bogeski I, Warscheid B, Chacinska A, Rehling P. COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria. J Mol Biol. 2020 Feb 13. doi: 10.1016/j.jmb.2020.01.036.

Lanin AA, Pochechuev MS, Chebotarev AS, Kelmanson IV, Bilan DS, Kotova DA, Tarabykin VS, Ivanov AA, Fedotov AB, Belousov VV, Zheltikov AM. (2020) Cell-specific three-photon-fluorescence brain imaging: neurons, astrocytes, and gliovascular interfaces. Opt Lett. 2020 Feb 15;45(4):836-839.

Gundelach, L. A., Huser, M. A., Beutner, D., Ruther, P. & Bruegmann, T. Towards the clinical translation of optogenetic skeletal muscle stimulation. Pflugers Arch 2020; doi:10.1007/s00424-020-02387-0.

Amblard I, Thauvin M, Rampon C, Queguiner I, Pak V, Belousov V, Prochiantz A, Volovitch M, Joliot A, Vriz S (2020) H2 O2 and Engrailed 2 paracrine activity synergize to shape the zebrafish optic tectum. COMMUN BIOL 3(1): 536, doi: 10.1038/s42003-020-01268-7

Kostyuk AI, Kokova AD, Podgorny OV, Kelmanson IV, Fetisova ES, Belousov VV, Bilan DS (2020) Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia. ANTIOXIDANTS-BASEL 9(6): 516, doi: 10.3390/antiox9060516

Kostyuk AI, Panova AS, Kokova AD, Kotova DA, Maltsev DI, Podgorny OV, Belousov VV, Bilan DS (2020 In Vivo Imaging with Genetically Encoded Redox Biosensors. INT J MOL SCI 21(21): -, doi: 10.3390/ijms21218164

2019

Akula AK, Zhang X, Viotti JS, Nestvogel D, Rhee JS, Ebrecht R, Reim K, Wouters F, Liepold T, Jahn O, Bogeski I, Dresbach T (2019) The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting. FRONT MOL NEUROSCI 12: 249, doi: 10.3389/fnmol.2019.00249

Asfaw KG, Liu Q, Maisch J, Münch SW, Wehl I, Bräse S, Bogeski I, Schepers U, Nick P (2019) A Peptoid Delivers CoQ-derivative to Plant Mitochondria via Endocytosis. SCI REP-UK 9(1): 9839, doi: 10.1038/s41598-019-46182-z

Chugunova A, Loseva E, Mazin P, Mitina A, Navalayeu T, Bilan D, Vishnyakova P, Marey M, Golovina A, Serebryakova M, Pletnev P, Rubtsova M, Mair W, Vanyushkina A, Khaitovich P, Belousov V, Vysokikh M, Sergiev P, Dontsova O (2019) LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism. P NATL ACAD SCI USA 116(11): 4940-4945, doi: 10.1073/pnas.1809105116

Ermakova YG, Mishina NM, Schultz C, Belousov VV (2019) Visualization of Intracellular Hydrogen Peroxide with the Genetically Encoded Fluorescent Probe HyPer in NIH-3T3 Cells. Methods Mol Biol 1982: 259-274, doi: 10.1007/978-1-4939-9424-3_15

Fandrey J, Schödel J, Eckardt KU, Katschinski DM, Wenger RH (2019) Now a Nobel gas: oxygen. PFLUG ARCH EUR J PHY 471(11-12): 1343-1358, doi: 10.1007/s00424-019-02334-8

Funken M, Malan D, Sasse P, Bruegmann T (2019) Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia. FRONT PHYSIOL 10: 498, doi: 10.3389/fphys.2019.00498

Gibhardt CS, Vultur A, Bogeski I (2019) Measuring Calcium and ROS by Genetically Encoded Protein Sensors and Fluorescent Dyes. Methods Mol Biol 1925: 183-196, doi: 10.1007/978-1-4939-9018-4_17

Kostyuk AI, Demidovich AD, Kotova DA, Belousov VV, Bilan DS (2019) Circularly Permuted Fluorescent Protein-Based Indicators: History, Principles, and Classification. INT J MOL SCI 20(17): -, doi: 10.3390/ijms20174200

Leinhos L, Peters J, Krull S, Helbig L, Vogler M, Levay M, van Belle GJ, Ridley AJ, Lutz S, Katschinski DM, Zieseniss A (2019) Hypoxia suppresses myofibroblast differentiation by changing RhoA activity. J CELL SCI 132(5): -, doi: 10.1242/jcs.223230

Makowka P, Bruegmann T, Dusend V, Malan D, Beiert T, Hesse M, Fleischmann BK, Sasse P (2019) Optogenetic stimulation of Gs -signaling in the heart with high spatio-temporal precision. NAT COMMUN 10(1): 1281, doi: 10.1038/s41467-019-09322-7

Mishina NM, Bogdanova YA, Ermakova YG, Panova AS, Kotova DA, Bilan DS, Steinhorn B, Arnér ESJ, Michel T, Belousov VV (2019) Which Antioxidant System Shapes Intracellular H2 O2 Gradients? ANTIOXID REDOX SIGN 31(9): 664-670, doi: 10.1089/ars.2018.7697

Nanadikar MS, Vergel Leon AM, Borowik S, Hillemann A, Zieseniss A, Belousov VV, Bogeski I, Rehling P, Dudek J, Katschinski DM (2019) O2 affects mitochondrial functionality ex vivo. REDOX BIOL 22: 101152, doi: 10.1016/j.redox.2019.101152

Neubert E, Bach KM, Busse J, Bogeski I, Schön MP, Kruss S, Erpenbeck L (2019) Blue and Long-Wave Ultraviolet Light Induce in vitro Neutrophil Extracellular Trap (NET) Formation. FRONT IMMUNOL 10: 2428, doi: 10.3389/fimmu.2019.02428

Pochechuev MS, Lanin AA, Kelmanson IV, Bilan DS, Kotova DA, Chebotarev AS, Tarabykin V, Fedotov AB, Belousov VV, Zheltikov AM (2019) Stain-free subcellular-resolution astrocyte imaging using third-harmonic generation. OPT LETT 44(12): 3166-3169, doi: 10.1364/OL.44.003166

Richter C, Bruegmann T (2019) No light without the dark: Perspectives and hindrances for translation of cardiac optogenetics. PROG BIOPHYS MOL BIO -: -, doi: 10.1016/j.pbiomolbio.2019.08.013

Sasse P, Funken M, Beiert T, Bruegmann T (2019) Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application? FRONT PHYSIOL 10: 675, doi: 10.3389/fphys.2019.00675

Schley G, Klanke B, Kalucka J, Schatz V, Daniel C, Mayer M, Goppelt-Struebe M, Herrmann M, Thorsteinsdottir M, Palsson R, Beneke A, Katschinski DM, Burzlaff N, Eckardt KU, Weidemann A, Jantsch J, Willam C (2019) Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis. KIDNEY INT 96(2): 378-396, doi: 10.1016/j.kint.2019.02.016

Schmidt B, Alansary D, Bogeski I, Niemeyer BA, Rieger H (2019) Reaction-diffusion model for STIM-ORAI interaction: The role of ROS and mutations. J THEOR BIOL 470: 64-75, doi: 10.1016/j.jtbi.2019.02.010

Shokhina AG, Kostyuk AI, Ermakova YG, Panova AS, Staroverov DB, Egorov ES, Baranov MS, van Belle GJ, Katschinski DM, Belousov VV, Bilan DS (2019) Red fluorescent redox-sensitive biosensor Grx1-roCherry. REDOX BIOL 21: 101071, doi: 10.1016/j.redox.2018.101071

Trautsch I, Heta E, Soong PL, Levent E, Nikolaev VO, Bogeski I, Katschinski DM, Mayr M, Zimmermann WH (2019) Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium. FRONT PHYSIOL 10: 272, doi: 10.3389/fphys.2019.00272

Zhang X, Gibhardt CS, Will T, Stanisz H, Körbel C, Mitkovski M, Stejerean I, Cappello S, Pacheu-Grau D, Dudek J, Tahbaz N, Mina L, Simmen T, Laschke MW, Menger MD, Schön MP, Helms V, Niemeyer BA, Rehling P, Vultur A, Bogeski I (2019) Redox signals at the ER-mitochondria interface control melanoma progression. EMBO J 38(15): e100871, doi: 10.15252/embj.2018100871

2018

Bilan DS, Belousov VV (2018) In Vivo Imaging of Hydrogen Peroxide with HyPer Probes. ANTIOXID REDOX SIGN 29(6): 569-584, doi: 10.1089/ars.2018.7540

Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, Bernhard O, Balleiniger M, Alfar EA, Zieseniss A, Toischer K, Guan K, Rizzoli SO, Brügger B, Fischer A, Katschinski DM, Rehling P, Dudek J (2018) Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. CELL REP 25(3): 561-570.e6, doi: 10.1016/j.celrep.2018.09.057

Ermakova YG, Pak VV, Bogdanova YA, Kotlobay AA, Yampolsky IV, Shokhina AG, Panova AS, Marygin RA, Staroverov DB, Bilan DS, Sies H, Belousov VV (2018) SypHer3s: a genetically encoded fluorescent ratiometric probe with enhanced brightness and an improved dynamic range. CHEM COMMUN 54(23): 2898-2901, doi: 10.1039/c7cc08740c

Klein MC, Zimmermann K, Schorr S, Landini M, Klemens PAW, Altensell J, Jung M, Krause E, Nguyen D, Helms V, Rettig J, Fecher-Trost C, Cavalié A, Hoth M, Bogeski I, Neuhaus HE, Zimmermann R, Lang S, Haferkamp I (2018) AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum. NAT COMMUN 9(1): 3489, doi: 10.1038/s41467-018-06003-9

Kostyuk AI, Panova AS, Bilan DS, Belousov VV (2018) Redox biosensors in a context of multiparameter imaging. FREE RADICAL BIO MED 128: 23-39, doi: 10.1016/j.freeradbiomed.2018.04.004

Pedre B, Young D, Charlier D, Mourenza Á, Rosado LA, Marcos-Pascual L, Wahni K, Martens E, G de la Rubia A, Belousov VV, Mateos LM, Messens J (2018) Structural snapshots of OxyR reveal the peroxidatic mechanism of H2 O2 sensing. P NATL ACAD SCI USA 115(50): E11623-E11632, doi: 10.1073/pnas.1807954115

Roshchin M, Ermakova YG, Lanin AA, Chebotarev AS, Kelmanson IV, Balaban PM, Zheltikov AM, Belousov VV, Nikitin ES (2018) Thermogenetic stimulation of single neocortical pyramidal neurons transfected with TRPV1-L channels. NEUROSCI LETT 687: 153-157, doi: 10.1016/j.neulet.2018.09.038

Roshchin MV, Matlashov ME, Ierusalimsky VN, Balaban PM, Belousov VV, Kemenes G, Staras K, Nikitin ES (2018) A BK channel-mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing. SCI ADV 4(7): eaat1357, doi: 10.1126/sciadv.aat1357

Steinhorn B, Sorrentino A, Badole S, Bogdanova Y, Belousov V, Michel T (2018) Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction. NAT COMMUN 9(1): 4044, doi: 10.1038/s41467-018-06533-2

Swain L, Nanadikar MS, Borowik S, Zieseniss A, Katschinski DM (2018) Transgenic Organisms Meet Redox Bioimaging: One Step Closer to Physiology. ANTIOXID REDOX SIGN 29(6): 603-612, doi: 10.1089/ars.2017.7469

Vultur A, Gibhardt CS, Stanisz H, Bogeski I (2018) The role of the mitochondrial calcium uniporter (MCU) complex in cancer. PFLUG ARCH EUR J PHY 470: 1149-1163, doi: 10.1007/s00424-018-2162-8

Zhang X, Gibhardt CS, Cappello S, Zimmermann KM, Vultur A, Bogeski I (2018) Measuring Mitochondrial ROS in Mammalian Cells with a Genetically Encoded Protein Sensor. bio-protocol 8: -

Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC, Hoth M (2018) A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity. J PHYSIOL-LONDON 596(14): 2681-2698, doi: 10.1113/JP274964

2017

Beneke A, Guentsch A, Hillemann A, Zieseniss A, Swain L, Katschinski DM (2017) Loss of PHD3 in myeloid cells dampens the inflammatory response and fibrosis after hind-limb ischemia. CELL DEATH DIS 8(8): e2976, doi: 10.1038/cddis.2017.375

Bozem M, Knapp P, Mirčeski V, Slowik EJ, Bogeski I, Kappl R, Heinemann C, Hoth M (2017) Electrochemical Quantification of Extracellular Local H2O2 Kinetics Originating from Single Cells. ANTIOXID REDOX SIGN -: -, doi: 10.1089/ars.2016.6840

Burckhardt BC, Burckhardt G (2017) Interaction of Excitatory Amino Acid Transporters 1 - 3 (EAAT1, EAAT2, EAAT3) with N-Carbamoylglutamate and N-Acetylglutamate. Cell Physiol Biochem 43(5): 1907-1916, doi: 10.1159/000484110

Burckhardt BC, Henjakovic M, Hagos Y, Burckhardt G (2017) Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. J PHARMACOL EXP THER 362(3): 450-458, doi: 10.1124/jpet.117.241406

Dullin C, Ufartes R, Larsson E, Martin S, Lazzarini M, Tromba G, Missbach-Guentner J, Pinkert-Leetsch D, Katschinski DM, Alves F (2017) μCT of ex-vivo stained mouse hearts and embryos enables a precise match between 3D virtual histology, classical histology and immunochemistry. PLOS ONE 12(2): e0170597, doi: 10.1371/journal.pone.0170597

Ermakova YG, Lanin AA, Fedotov IV, Roshchin M, Kelmanson IV, Kulik D, Bogdanova YA, Shokhina AG, Bilan DS, Staroverov DB, Balaban PM, Fedotov AB, Sidorov-Biryukov DA, Nikitin ES, Zheltikov AM, Belousov VV (2017) Thermogenetic neurostimulation with single-cell resolution. NAT COMMUN 8: 15362, doi: 10.1038/ncomms15362

Frischauf I, Litviňuková M, Schober R, Zayats V, Svobodová B, Bonhenry D, Lunz V, Cappello S, Tociu L, Reha D, Stallinger A, Hochreiter A, Pammer T, Butorac C, Muik M, Groschner K, Bogeski I, Ettrich RH, Romanin C, Schindl R (2017) Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription. SCI SIGNAL 10(507): -, doi: 10.1126/scisignal.aao0358

Guentsch A, Beneke A, Swain L, Farhat K, Nagarajan S, Wielockx B, Raithatha K, Dudek J, Rehling P, Zieseniss A, Jatho A, Chong M, Santos CXC, Shah AM, Katschinski DM (2017) PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages. MOL CELL BIOL 37(1): 1-16, doi: 10.1128/MCB.00236-16

Kozlova N, Wottawa M, Katschinski DM, Kristiansen G, Kietzmann T (2017) Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget 8(6): 9885-9898, doi: 10.18632/oncotarget.14241

Niebert S, van Belle GJ, Vogelgesang S, Manzke T, Niebert M (2017) The Serotonin Receptor Subtype 5b Specifically Interacts with Serotonin Receptor Subtype 1A. FRONT MOL NEUROSCI 10: 299, doi: 10.3389/fnmol.2017.00299

Rahbari M, Rahlfs S, Jortzik E, Bogeski I, Becker K (2017) H2O2 dynamics in the malaria parasite Plasmodium falciparum. PLOS ONE 12(4): e0174837, doi: 10.1371/journal.pone.0174837

Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM (2017) Hypoxia-stimulated membrane trafficking requires T-plastin. ACTA PHYSIOL 221(1): 59-73, doi: 10.1111/apha.12859

Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz EC, Hamed M, Bogeski I, Helms V, Rieger H, Qu B (2017) Bystander cells enhance NK cytotoxic efficiency by reducing search time. SCI REP-UK 7: 44357, doi: 10.1038/srep44357

2016

Burckhardt BC, Henjakovic M, Hagos Y, Burckhardt G (2016) Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3). PFLUG ARCH EUR J PHY 468(11-12): 1909-1918, doi: 10.1007/s00424-016-1894-6

Hoogewijs D, Vogler M, Zwenger E, Krull S, Zieseniss A (2016) Oxygen-dependent regulation of aquaporin-3 expression. Hypoxia (Auckl) 4: 91-97, doi: 10.2147/HP.S97681

Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Güntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM (2016) Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice. CIRC RES 119(9): 1004-1016, doi: 10.1161/CIRCRESAHA.116.309551

2015

Babelova A, Burckhardt BC, Salinas-Riester G, Pommerenke C, Burckhardt G, Henjakovic M (2015) Next generation sequencing of sex-specific genes in the livers of obese ZSF1 rats. GENOMICS 106(4): 204-13, doi: 10.1016/j.ygeno.2015.07.006

Babelova A, Burckhardt BC, Wegner W, Burckhardt G, Henjakovic M (2015) Sex-differences in renal expression of selected transporters and transcription factors in lean and obese zucker spontaneously hypertensive Fatty rats. J DIABETES RES 2015: 483238, doi: 10.1155/2015/483238

Breljak D, Brzica H, Vrhovac I, Micek V, Karaica D, Ljubojević M, Sekovanić A, Jurasović J, Rašić D, Peraica M, Lovrić M, Schnedler N, Henjakovic M, Wegner W, Burckhardt G, Burckhardt BC, Sabolić I (2015) In female rats, ethylene glycol treatment elevates protein expression of hepatic and renal oxalate transporter sat-1 (Slc26a1) without inducing hyperoxaluria. CROAT MED J 56(5): 447-59

Czepluch FS, Vogler M, Kuschicke H, Meier J, Gogiraju R, Katschinski DM, Riggert J, Hasenfuss G, Schäfer K (2015) Circulating Endothelial Cells Expressing the Angiogenic Transcription Factor Krüppel-Like Factor 4 are Decreased in Patients with Coronary Artery Disease. MICROCIRCULATION 22(8): 700-10, doi: 10.1111/micc.12226

Henjakovic M, Hagos Y, Krick W, Burckhardt G, Burckhardt BC (2015) Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function. AM J PHYSIOL-RENAL 309(10): F843-51, doi: 10.1152/ajprenal.00140.2015

Jatho A, Hartmann S, Kittana N, Mügge F, Wuertz CM, Tiburcy M, Zimmermann WH, Katschinski DM, Lutz S (2015) RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes. PLOS ONE 10(10): e0137519, doi: 10.1371/journal.pone.0137519

Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R (2015) Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. NAT MED 21(9): 998-1009, doi: 10.1038/nm.3902

Schulz K, Hagos Y, Burckhardt G, Schley G, Burzlaff N, Willam C, Burckhardt BC (2015) The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3. NEPHRON 131(4): 285-9, doi: 10.1159/000442531

Schweikhard ES, Burckhardt BC, Joos F, Fenollar-Ferrer C, Forrest LR, Kempson SA, Ziegler C (2015) Role of N-glycosylation in renal betaine transport. BIOCHEM J 470(2): 169-79, doi: 10.1042/BJ20131031

Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen. CELL REP 13(10): 2048-55, doi: 10.1016/j.celrep.2015.11.005

Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski DM (2015) Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. PFLUG ARCH EUR J PHY 467(10): 2141-9, doi: 10.1007/s00424-014-1667-z

Zieseniss A, Hesse AR, Jatho A, Krull S, Hölscher M, Vogel S, Katschinski DM (2015) Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia. Cell Physiol Biochem 36(3): 843-51, doi: 10.1159/000430260

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